Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

Abstract

In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation.

Keywords

• rac-gef
• tyrosine kinase receptor
• metastasis
• kras
• lung adenocarcinoma