Nature Communications (Nov 2020)

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

  • Veselina Petrova,
  • Craig S. Pearson,
  • Jared Ching,
  • James R. Tribble,
  • Andrea G. Solano,
  • Yunfei Yang,
  • Fiona M. Love,
  • Robert J. Watt,
  • Andrew Osborne,
  • Evan Reid,
  • Pete A. Williams,
  • Keith R. Martin,
  • Herbert M. Geller,
  • Richard Eva,
  • James W. Fawcett

DOI
https://doi.org/10.1038/s41467-020-19436-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Increasing the supply of growth machinery to axons is a potential strategy for promoting repair after injury. Here the authors demonstrate that the endoplasmic reticulum adaptor molecule Protrudin provides cellular components that support axonal regeneration in the adult CNS.