Nature Communications (Nov 2020)
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS
- Veselina Petrova,
- Craig S. Pearson,
- Jared Ching,
- James R. Tribble,
- Andrea G. Solano,
- Yunfei Yang,
- Fiona M. Love,
- Robert J. Watt,
- Andrew Osborne,
- Evan Reid,
- Pete A. Williams,
- Keith R. Martin,
- Herbert M. Geller,
- Richard Eva,
- James W. Fawcett
Affiliations
- Veselina Petrova
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Craig S. Pearson
- Laboratory of Developmental Neurobiology, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH
- Jared Ching
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- James R. Tribble
- Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet
- Andrea G. Solano
- Laboratory of Developmental Neurobiology, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH
- Yunfei Yang
- Department of Ophthalmology, Addenbrooke’s Hospital
- Fiona M. Love
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Robert J. Watt
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Andrew Osborne
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Evan Reid
- Cambridge Institute for Medical Research and Department of Medical Genetics, University of Cambridge
- Pete A. Williams
- Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet
- Keith R. Martin
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Herbert M. Geller
- Laboratory of Developmental Neurobiology, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH
- Richard Eva
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- James W. Fawcett
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-19436-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Increasing the supply of growth machinery to axons is a potential strategy for promoting repair after injury. Here the authors demonstrate that the endoplasmic reticulum adaptor molecule Protrudin provides cellular components that support axonal regeneration in the adult CNS.
