Journal of Clinical and Diagnostic Research (Dec 2021)

Comparison of Pritchard and Dhaka Regimen in Outcome of Patients with Severe Preeclampsia and Eclampsia in Eastern Part of India: A Prospective Observational Study

  • anjali rani,
  • Madhu Jain,
  • debbrata das,
  • kamlesh kumar,
  • Milad Mohammadzadehasl

DOI
https://doi.org/10.7860/JCDR/2021/51814.15741
Journal volume & issue
Vol. 15, no. 12
pp. 06 – 09

Abstract

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Introduction: Preeclampsia and eclampsia are one of the leading causes of maternal mortality. Magnesium sulphate is the drug of choice to prevent and avoid recurrences of convulsions. Pritchard is the standard regimen of Magnesium sulfate (MgSO4 ). But keeping in view the small stature and low Body Mass Index (BMI) of Indian women low dose regimen of MgSO4 (Dhaka regimen) is also effective. Aim: To compare the efficacy of Pritchard and Dhaka regimen in control of convulsions in severe preeclampsia and eclampsia. Materials and Methods: A prospective observational study was done at Institute Of Medical Sciences-Banaras Hindu University, Varanasi, Uttar Pradesh, India, in Department of Obstetrics and Gynaecology in collaboration with Department of Biochemistry from January 2019 to December 2020. Two groups were made. In group I standard Pritchard regimen (n=48) and in group II Dhaka regimen (n=36) was given. Outcome was measured in terms of recurrence of convulsions, MgSO4 toxicity. Various parameters age, BMI, APGAR score, mode of delivery, birth weight were also measured. Student t-test was used to compare two groups. Results: The mean age in group I was 26.48±4.677 years and in group II was 24.64±3.743 years. Incidence of preeclampsia and eclampsia was 8.92%. The maternal mortality due to preeclampsia and eclampsia was 30.05%. Recurrence of convulsion was seen in two cases in group II and one case in group I. Serum magnesium level was statistically significant at 30 minute and at 4 hours. Various parameters like age, (p-value=0.056) duration of stay in hospital, (p-value=0.110) BMI, (p-value=0.304) mode of delivery (p-value=0.186) was not statistically significant. Conclusion: The low dose Dhaka is as effective as Standard Pritchard regimen. Magnesium sulphate toxicity was seen in three cases in Pritchard and not in single case in Dhaka regimen. It is a better choice for women of short stature of Asian women as it is less toxic.

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