Giant cell tumor of soft tissue of the nasopharynx: A case report

Abstract

Primary soft tissue giant cell tumors are rare. Although these tumors resemble their osseous counterparts, sequencing studies have suggested that these two may be genetically distinct. Treatment guidelines are less clear for this tumor type compared to giant cell tumor of the bone. Surgical excision is the standard of treatment; but for those with unresectable disease treatment options are less certain. For patients with unresectable tumors, the use of bisphosphonates and RANK-L directed biologic therapy have been described in the literature.We report a case of a nasopharyngeal giant cell tumor, which is an uncommon presentation of a rare soft tissue tumor. While surgery is the preferred treatment for this disease, the location of this tumor precluded resection. This has prompted the decision to employ systemic treatment with Zoledronic acid and subsequently Denosumab for the treatment of this patient.

Keywords

• Giant cell tumor of soft tissue (GCT-ST)
• Zoledronic acid
• Denosumab