Analysis of Correlation Between Serum Oncostatin-M and Disease Severity and Mortality in Hospitalized Patients with Community-Acquired Pneumonia

Abstract

Peikun Teng,1 Xingyu Zhang,2 Hong Wang,3 Xiudi Han,4 Xuedong Liu4 1General Medicine Dapartment, Qingdao Municipal Hospital, Qingdao, 266000, People’s Republic of China; 2Human Resources Department, Qingdao Municipal Hospital, Qingdao, 266000, People’s Republic of China; 3Hospital-Acquired Infection Control Department, Qingdao Municipal Hospital, Qingdao, 266000, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, 266000, People’s Republic of ChinaCorrespondence: Xuedong Liu; Xiudi Han, Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, 266000, People’s Republic of China, Email [email protected]; [email protected]: The aim of this study was to investigate the level of serum tumor suppressor factor (Oncostatin-M, OSM) in patients with community-acquired pneumonia (CAP) and evaluate its predictive value for the severity and prognosis of pneumonia, so as to improve the ability to identify the risk of death in CAP patients.Patients and Methods: A total of 110 patients with CAP admitted to the hospital from November 2020 to November 2021 were enrolled in this prospective study. Clinical data of all patients were collected. According to the 2016 edition of “Guidelines for the Diagnosis and Treatment of Community-acquired Pneumonia in Chinese Adults”, the patients were divided into non-severe CAP (NSCAP)(n=55) and severe CAP (SCAP)(n=55). At the same time, they were divided into a survival group (n=96) and a death group (n=14) by tracking the survival of patients in the hospital. The OSM concentration of CAP patients on the first day after admission was determined by enzyme-linked immunosorbent assay. All clinical data were statistically and graphed using SPSS V23.0 and Grahpad Prim 8.Results: Compared with NSCAP, patients with SCAP had higher serum OSM concentration on the day of admission, which was negatively correlated with LYM and positively correlated with WBC, NEU, CRP, IL-6, IL-8, IL-10, CURB-65 score, and PSI score. The level of OSM in the dead patient group was significantly higher than that in the surviving patient group. OSM and PSI scores were independent risk factors for in-hospital mortality in CAP patients. Kaplan-Meier survival curve showed that OSM≥ 76pg/mL was more advantageous in predicting mortality in patients with CAP.Conclusion: The level of the OSM is closely related to the severity and prognosis of CAP and may be a new biomarker for the prognosis of CAP patients.Keywords: community-acquired pneumonia, severity of disease, oncostatin-M, mortality

Keywords

• community-acquired pneumonia；severity of disease；oncostatin-m；mortality