Advances in hematopoietic stem cell transplantation for autoimmune diseases
Yuxi Xu,
Xiaoqi Wang,
Ziyi Hu,
Ruihao Huang,
Guancui Yang,
Rui Wang,
Shijie Yang,
Liyan Guo,
Qingxiao Song,
Jin Wei,
Xi Zhang
Affiliations
Yuxi Xu
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Xiaoqi Wang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Ziyi Hu
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Ruihao Huang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Guancui Yang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Rui Wang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Shijie Yang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Liyan Guo
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Qingxiao Song
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China; Corresponding author. Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China.
Jin Wei
Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Corresponding author. Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China.
Xi Zhang
Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China; Corresponding author. Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China.
Autoimmune diseases (ADs) are a collection of immunological disorders in which the immune system responds to self-antigens by producing autoantibodies or self-sensitized cells. Current treatments are unable to cure ADs, and achieving long-term drug-free remission remains a challenging task. Hematopoietic stem cell transplantation (HSCT) stands out from other therapies by specifically targeting ADs that target various cell subpopulations, demonstrating notable therapeutic benefits and resulting in sustained drug-free remission. Since different ADs have distinct mechanisms of action, the comprehensive understanding of how HSCT works in treating ADs is crucial. This review provides a detailed overview of the latest research and clinical applications of HSCT in treating ADs, offering new insights for clinicians aiming to optimize its use for ADs management.
