EFFECT OF PROGRESSION ATRIAL FIBRILLATION THE LEVEL OF MATRIX METALLOPROTEINASE-9

Abstract

Atrial fibrillation (AF) is one of the most common diseases in clinical practice. Experimental and clinical studies showed the existence of relationship between AF and changes in atrial electrical properties. The aim of the study – to investigate the levels of matrix metalloproteinase-9 (MMP-9) and to evaluate its significance and role in the various stages of the development of idiopathic atrial fibrillation (AF). Materials and Methods. The study included patients with idiopathic AF. In accordance with the degree of disease progression, patients were divided into 3 groups: paroxysmal, persistent and chronic AF. The control group consisted of practically healthy patients. To determine the serum levels of MMP-9 we used the double-antibody immunoassay with the enzyme label. Results and Discussion. Each study group consisted of 20 patients; the control group consisted of 40 patients. The level of MMP-9 in the treatment groups was significantly different from the control and amounted to: 170.62 ± 24.65, 202.33 ± 29.18, 252.3 ± 21.87 ng / ml for paroxysmal, persistent and chronic forms of AF and 75 78 ± 14.7 ng / ml in the control group, respectively. As the disease progresses the level of MMP-9 increased (p<0.05). Conclusions. Increased levels of MMP-9 is likely associated with the development and progression of idiopathic AF.

Keywords

• фібриляція передсердь
• позаклітинний матрикс
• матриксна металопротеїназа-9
• патологічні механізми.