Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh3/I2

Humaira Yasmeen Gondal; Zain Maqsood Cheema; Javid Hussain Zaidi; Sammer Yousuf; M. Iqbal Choudhary

doi:10.1186/s13065-018-0421-6

Chemistry Central Journal (May 2018)

Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh3/I2

Humaira Yasmeen Gondal,
Zain Maqsood Cheema,
Javid Hussain Zaidi,
Sammer Yousuf,
M. Iqbal Choudhary

Affiliations

Humaira Yasmeen Gondal: Department of Chemistry, University of Sargodha
Zain Maqsood Cheema: Department of Chemistry, University of Sargodha
Javid Hussain Zaidi: Department of Chemistry, Quaid-i-Azam University
Sammer Yousuf: H.E.J Research Institute of Chemistry, ICCBS, University of Karachi
M. Iqbal Choudhary: H.E.J Research Institute of Chemistry, ICCBS, University of Karachi

DOI: https://doi.org/10.1186/s13065-018-0421-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Abstract An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh3/I2 combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70–91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes.

Published in Chemistry Central Journal

ISSN: 1752-153X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://bmcchem.biomedcentral.com/

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Abstract

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