Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Ketan Mishra; Keerat Junday; Claire M.Y. Wong; Andrea Y. Chan; Stephanie Hesselson; David W. Muller; Siiri E. Iismaa; Ashish Mehta; Robert M. Graham

Stem Cell Research (Dec 2019)

Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Ketan Mishra,
Keerat Junday,
Claire M.Y. Wong,
Andrea Y. Chan,
Stephanie Hesselson,
David W. Muller,
Siiri E. Iismaa,
Ashish Mehta,
Robert M. Graham

Affiliations

Ketan Mishra: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
Keerat Junday: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
Claire M.Y. Wong: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
Andrea Y. Chan: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
Stephanie Hesselson: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia
David W. Muller: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia
Siiri E. Iismaa: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia
Ashish Mehta: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia
Robert M. Graham: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia; Corresponding author.

Journal volume & issue: Vol. 41

Abstract

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Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44–55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells. Keywords: SCAD, Induced pluripotent stem cells, Disease modeling, Cardiovascular biology, Reprogramming

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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