Nature Communications (Oct 2022)
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice
- Jennifer T. Wolstenholme,
- Justin M. Saunders,
- Maren Smith,
- Jason D. Kang,
- Phillip B. Hylemon,
- Javier González-Maeso,
- Andrew Fagan,
- Derrick Zhao,
- Masoumeh Sikaroodi,
- Jeremy Herzog,
- Amirhossein Shamsaddini,
- Marcela Peña-Rodríguez,
- Lianyong Su,
- Yun-Ling Tai,
- Jing Zheng,
- Po-Cheng Cheng,
- R. Balfour Sartor,
- Patrick M. Gillevet,
- Huiping Zhou,
- Jasmohan S. Bajaj
Affiliations
- Jennifer T. Wolstenholme
- VCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth University
- Justin M. Saunders
- Department of Physiology and Biophysics, Virginia Commonwealth University
- Maren Smith
- VCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth University
- Jason D. Kang
- Microbiology and Immunology, Virginia Commonwealth University
- Phillip B. Hylemon
- Department of Physiology and Biophysics, Virginia Commonwealth University
- Javier González-Maeso
- Department of Physiology and Biophysics, Virginia Commonwealth University
- Andrew Fagan
- Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center
- Derrick Zhao
- Microbiology and Immunology, Virginia Commonwealth University
- Masoumeh Sikaroodi
- Microbiome Analysis Center, George Mason University
- Jeremy Herzog
- National Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill
- Amirhossein Shamsaddini
- Microbiome Analysis Center, George Mason University
- Marcela Peña-Rodríguez
- University Center for Health Sciences, University of Guadalajara
- Lianyong Su
- Microbiology and Immunology, Virginia Commonwealth University
- Yun-Ling Tai
- Microbiology and Immunology, Virginia Commonwealth University
- Jing Zheng
- Microbiology and Immunology, Virginia Commonwealth University
- Po-Cheng Cheng
- Microbiology and Immunology, Virginia Commonwealth University
- R. Balfour Sartor
- National Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill
- Patrick M. Gillevet
- Microbiome Analysis Center, George Mason University
- Huiping Zhou
- Microbiology and Immunology, Virginia Commonwealth University
- Jasmohan S. Bajaj
- Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-34054-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool samples collected in the trial to report that this phenotype is transmissible via microbial transfer to germ free mice, as assessed by reduced ethanol acceptance, intake and preference.
