Photoluminescent Hydroxylapatite: Eu<sup>3+</sup> Doping Effect on Biological Behaviour
Ecaterina Andronescu,
Daniela Predoi,
Ionela Andreea Neacsu,
Andrei Viorel Paduraru,
Adina Magdalena Musuc,
Roxana Trusca,
Ovidiu Oprea,
Eugenia Tanasa,
Otilia Ruxandra Vasile,
Adrian Ionut Nicoara,
Adrian Vasile Surdu,
Florin Iordache,
Alexandra Catalina Birca,
Simona Liliana Iconaru,
Bogdan Stefan Vasile
Affiliations
Ecaterina Andronescu
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Daniela Predoi
Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, 077125 Magurele, Romania
Ionela Andreea Neacsu
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Andrei Viorel Paduraru
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Adina Magdalena Musuc
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Roxana Trusca
National Centre for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Ovidiu Oprea
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Eugenia Tanasa
National Centre for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Otilia Ruxandra Vasile
National Centre for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Adrian Ionut Nicoara
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Adrian Vasile Surdu
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Florin Iordache
Faculty of Veterinary Medicine, Department of Biochemistry, University of Agronomic Science and Veterinary Medicine, 011464 Bucharest, Romania
Alexandra Catalina Birca
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Simona Liliana Iconaru
Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, 077125 Magurele, Romania
Bogdan Stefan Vasile
Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
Luminescent europium-doped hydroxylapatite (EuXHAp) nanomaterials were successfully obtained by co-precipitation method at low temperature. The morphological, structural and optical properties were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), UV-Vis and photoluminescence (PL) spectroscopy. The cytotoxicity and biocompatibility of EuXHAp were also evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) assay, oxidative stress assessment and fluorescent microscopy. The results reveal that the Eu3+ has successfully doped the hexagonal lattice of hydroxylapatite. By enhancing the optical features, these EuXHAp materials demonstrated superior efficiency to become fluorescent labelling materials for bioimaging applications.
