Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines

Abstract

The objective of this work was to advance implantable Ruthenium complexes incorporated polycaprolactone (PCL-Ru) electrospun nanofibers, which might hold great potential for cancer diagnosis. Ruthenium complex was infused into biodegradable PCL nanofibers by the electrospinning method and was characterized for their structural and surface morphology using FESEM, HRTEM, and XRD. The chemical analysis was performed through FTIR and UV–Vis. The mechanical strength and thermal behavior of the electrospun nanofibrous have been examined in this study. The average diameter of pristine PCL and PCL-Ru nanofibers was 617.91 ± 165 nm and 426.77 ± 14 nm. The in vitro anticancer activity of Ru-complexes infused PCL nanofibers was assessed against liver (Hep-G2), oral cancer (HSC-3), renal cell carcinomas (ACHN), and lung (L-132) cancer cell lines, as well as the release profile of the Ru-complexes, infused PCL nanofibers. According to the results, Ru-complexes containing PCL may be easily infused into nanofibers and have a very uniform distribution inside them. More significantly, the Ru-complexes produced by the blended nanofibers can be released for an extended of period time, resulting in significant anticancer efficacy in vitro.

Keywords

• Ruthenium complexes
• Electrospinning
• Polycaprolactone
• Anticancer activity