Data highlighting phenotypic diversity of urine-associated Escherichia coli isolates
Allison R. Eberly,
Connor J. Beebout,
Ching Man Carmen Tong,
Gerald T. Van Horn,
Hamilton D. Green,
Madison J. Fitzgerald,
Shuvro De,
Emily K. Apple,
Alexandra C. Schrimpe-Rutledge,
Simona G. Codreanu,
Stacy D. Sherrod,
John A. McLean,
Douglass B. Clayton,
Charles W. Stratton,
Jonathan E. Schmitz,
Maria Hadjifrangiskou
Affiliations
Allison R. Eberly
Division of Molecular Pathogenesis and
Connor J. Beebout
Division of Molecular Pathogenesis and
Ching Man Carmen Tong
Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN 37232
Gerald T. Van Horn
Division of Molecular Pathogenesis and
Hamilton D. Green
Division of Molecular Pathogenesis and
Madison J. Fitzgerald
Division of Molecular Pathogenesis and
Shuvro De
Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN 37232
Emily K. Apple
Division of Molecular Pathogenesis and
Alexandra C. Schrimpe-Rutledge
Center for Innovative Technologies, Department of Chemistry, Vanderbilt University, Nashville, TN 37232
Simona G. Codreanu
Center for Innovative Technologies, Department of Chemistry, Vanderbilt University, Nashville, TN 37232
Stacy D. Sherrod
Center for Innovative Technologies, Department of Chemistry, Vanderbilt University, Nashville, TN 37232
John A. McLean
Center for Innovative Technologies, Department of Chemistry, Vanderbilt University, Nashville, TN 37232
Douglass B. Clayton
Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN 37232
Charles W. Stratton
Division of Molecular Pathogenesis and; Division of Laboratory Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232; Vanderbilt Institute for Infection, Immunology & Inflammation (VI4), Vanderbilt University Medical Center, Nashville, TN 37232
Jonathan E. Schmitz
Division of Molecular Pathogenesis and; Division of Laboratory Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232; Vanderbilt Institute for Infection, Immunology & Inflammation (VI4), Vanderbilt University Medical Center, Nashville, TN 37232; Co-corresponding Author: Jonathan E. Schmitz, 4519 The Vanderbilt Clinic, 1211 Medical Center Drive, Nashville TN 37212, 615-343-1289
Maria Hadjifrangiskou
Division of Molecular Pathogenesis and; Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN 37232; Vanderbilt Institute for Infection, Immunology & Inflammation (VI4), Vanderbilt University Medical Center, Nashville, TN 37232; Corresponding Author: Maria Hadjifrangiskou, MCN AA-4210B, 1161 21st Ave South, Nashville TN 37212, 615-322-4851
This article provides a reusable dataset describing detailed phenotypic and associated clinical parameters in n=303 clinical isolates of urinary Escherichia coli collected at Vanderbilt University Medical Center. De-identified clinical data collected with each isolate are detailed here and correlated to biofilm abundance and metabolomics data. Biofilm-abundance data were collected for each isolate under different in vitro conditions along with datasets quantifying biofilm abundance of each isolate under different conditions. Metabolomics data were collected from a subset of bacterial strains isolated from uncomplicated cases of cystitis or cases with no apparent symptoms accompanying colonization. For more insight, please see “Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities” [1].
