Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome.

Abstract

BackgroundTroxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in high-fat diet-induced metabolic disorders. In this study, we tested the effect of TRX on metabolic syndrome-associated disorders using a non-obese model of metabolic syndrome-the Hereditary Hypertriglyceridaemic rats (HHTg).MethodsAdult male HHTg rats were fed standard diet without or with TRX (150 mg/kg bwt/day for 4 weeks).ResultsCompared to untreated rats, TRX supplementation in HHTg rats decreased serum glucose (pConclusionOur results indicate that TRX improves hepatic lipid metabolism and insulin sensitivity in peripheral tissues. As well as ameliorating oxidative stress, TRX can reduce ectopic lipid deposition, affect genes involved in lipid metabolism, and influence the activity of CYP family enzymes.