Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study

Haozheng Li; Hui Zhang; Shuai Xu; Mengxing Wang; Jilei Zhang; Jianren Liu; Xiaoxia Du; Ruiping Hu

doi:10.3390/brainsci13020300

Brain Sciences (Feb 2023)

Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study

Haozheng Li,
Hui Zhang,
Shuai Xu,
Mengxing Wang,
Jilei Zhang,
Jianren Liu,
Xiaoxia Du,
Ruiping Hu

Affiliations

Haozheng Li: Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Hui Zhang: Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China
Shuai Xu: Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China
Mengxing Wang: Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China
Jilei Zhang: Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China
Jianren Liu: Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Xiaoxia Du: Department of Psychology, Shanghai University of Sport, Shanghai 200438, China
Ruiping Hu: Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China

DOI: https://doi.org/10.3390/brainsci13020300
Journal volume & issue: Vol. 13, no. 2
p. 300

Abstract

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Purpose: Brain areas frequently implicated in language recovery after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying language restoration are still largely unclear. Methods and materials: In the present study, we investigated the brain function in 15 patients with poststroke aphasia and 30 matched control subjects by combining the regional homogeneity (ReHo) and amplitudes of low-frequency fluctuation (ALFF) analysis methods based on resting-state fMRI. Results: Compared to the control subjects, the patients with aphasia exhibited increased ReHo and ALFF values in the ipsilateral perilesional areas and increased ReHo in the contralesional right middle frontal gyrus. Conclusions: The increased spontaneous brain activity in patients with poststroke aphasia during the recovery period, specifically in the ipsilateral perilesional regions and the homologous language regions of the right hemisphere, has potential implications for the treatment of patients with aphasia.

Published in Brain Sciences

ISSN: 2076-3425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.mdpi.com/journal/brainsci/

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