Review: Bioengineering approach for the repair and regeneration of peripheral nerve

Joshua Moskow; Bryan Ferrigno; Nikhil Mistry; Devina Jaiswal; Ketan Bulsara; Swetha Rudraiah; Sangamesh G. Kumbar

Bioactive Materials (Dec 2019)

Review: Bioengineering approach for the repair and regeneration of peripheral nerve

Joshua Moskow,
Bryan Ferrigno,
Nikhil Mistry,
Devina Jaiswal,
Ketan Bulsara,
Swetha Rudraiah,
Sangamesh G. Kumbar

Affiliations

Joshua Moskow: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USA
Bryan Ferrigno: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA
Nikhil Mistry: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA
Devina Jaiswal: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USA
Ketan Bulsara: Department of Surgery, University of Connecticut Health, 263 Farmington Ave., Farmington, CT 06030, USA
Swetha Rudraiah: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Saint Joseph, 229 Trumbull St., Hartford CT 06103, USA
Sangamesh G. Kumbar: Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USA; Corresponding author. Department of Orthopaedic Surgery, Department of Biomedical Engineering, Department of Materials Science and Engineering, The University of Connecticut, Farmington, CT 06030-1320, USA.

Journal volume & issue: Vol. 4
pp. 107 – 113

Abstract

Read online

Complex craniofacial surgeries of damaged tissues have several limitations, which present complications and challenges when trying to replicate facial function and structure. Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks. As technology continues to advance, new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure. This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds, bioactive factors, and external stimuli alone or in combination to support peripheral nerve regeneration. Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. Keywords: Peripheral nerve regeneration, Composite materials, Growth factor, Electrical stimulation

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

About the journal