Acta Biomedica Scientifica (May 2012)

ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE BLOOD LYMPHOCYTES OF PATIENTS WITH LUNG CANCER

  • V. I. Minina,
  • M. L. Bakanova,
  • J. A. Savchenko,
  • A. A. Timopheyeva,
  • T. P. Anosova,
  • V. A. Titov,
  • N. E. Verghbizkaja,
  • A. N. Glushkov

Journal volume & issue
Vol. 0, no. 3(2)
pp. 121 – 124

Abstract

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Analysis of association, between several DNA repair gene polymorphisms and the level of chromosomal aberrations (CAs) in lymphocytes was performed in two groups: a group of 215 patients with lung cancer and a control group of 152 donors. In the group patient with lung cancer the level of CAs shows a significant increase in the carrier of genotypes: XPD TG and XPD GG vs XPD TT. In the control group level of CAs shows a significant increase in the carrier of genotype ADPRT ТС vs ТТ.

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