A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

Aditya Saxena; Uma Chaudhary; Alok Bharadwaj; Nitin Wahi; Jitender Reddy Kalli; Shravya Gupta; Sparsh Kumar; Somya Gupta; Utkarsh Raj

doi:10.22207/JPAM.14.SPL1.47

Journal of Pure and Applied Microbiology (May 2020)

A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

Aditya Saxena,
Uma Chaudhary,
Alok Bharadwaj,
Nitin Wahi,
Jitender Reddy Kalli,
Shravya Gupta,
Sparsh Kumar,
Somya Gupta,
Utkarsh Raj

Affiliations

Aditya Saxena: ORCiD; Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura - 281 406, India.
Uma Chaudhary: ORCiD; Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura - 281 406, India.
Alok Bharadwaj: ORCiD; Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura - 281 406, India.
Nitin Wahi: ORCiD; Department of Bioinformatics, Pathfinder Research and Training Foundation, Gr. Noida - 201 308, India.
Jitender Reddy Kalli: ORCiD; Department of Biotechnology and Bioinformatics, NIIT University, Neemrana - 301 705, Rajasthan, India.
Shravya Gupta: ORCiD; Department of Biotechnology and Bioinformatics, NIIT University, Neemrana - 301 705, Rajasthan, India.
Sparsh Kumar: ORCiD; Department of Biotechnology and Bioinformatics, NIIT University, Neemrana - 301 705, Rajasthan, India.
Somya Gupta: ORCiD; Department of Biotechnology and Bioinformatics, NIIT University, Neemrana - 301 705, Rajasthan, India.
Utkarsh Raj: ORCiD; Department of Biotechnology and Bioinformatics, NIIT University, Neemrana - 301 705, Rajasthan, India.

DOI: https://doi.org/10.22207/JPAM.14.SPL1.47
Journal volume & issue: Vol. 14, no. suppl 1
pp. 1077 – 1081

Abstract

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Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan, China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) which causes zoonotic sicknesses and represents a significant risk to general wellbeing. Recognizing the hidden biology and pathogenesis of this novel coronavirus is extremely critical to comprehend as well as boosting the treatment of this deadly pandemic. The point of this study is to recognize key genes which show significant expression in the SARS-CoV-2 infected lungs as compared to healthy ones. Our analysis uncovered 149 gene-signatures that show substantial up-regulation in COVID-19 lungs. Out of these, top ten dysregulated genes STAP1, CASP5, FDCSP, CARD17, ST20, AKR1B10, CLC, KCNJ2-AS1, RNASE2 and FLG are found to be significant based on various crucial statistical factors and may end up being acceptable helpful drug targets.

Published in Journal of Pure and Applied Microbiology

ISSN: 0973-7510 (Print); 2581-690X (Online)
Publisher: Journal of Pure and Applied Microbiology
Country of publisher: India
LCC subjects: Science: Microbiology
Website: https://www.microbiologyjournal.org/

About the journal

Abstract

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