Regulating the Regulators: microRNA and Asthma

Jia-wang Wang, PhD; Kunyu Li, BS; Gary Hellermann, PhD; Richard F. Lockey, MD; Subhra Mohapatra, PhD; Shyam Mohapatra, PhD

World Allergy Organization Journal (Jan 2011)

Regulating the Regulators: microRNA and Asthma

Jia-wang Wang, PhD,
Kunyu Li, BS,
Gary Hellermann, PhD,
Richard F. Lockey, MD,
Subhra Mohapatra, PhD,
Shyam Mohapatra, PhD

Affiliations

Jia-wang Wang, PhD: Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center, Tampa, FL 33612; Division of Allergy and Immunology, Tampa, FL 33612
Kunyu Li, BS: Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center, Tampa, FL 33612; Division of Allergy and Immunology, Tampa, FL 33612
Gary Hellermann, PhD: Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center, Tampa, FL 33612; Division of Allergy and Immunology, Tampa, FL 33612
Richard F. Lockey, MD: Division of Allergy and Immunology, Tampa, FL 33612; University of South Florida College of Medicine, and James A. Haley VA Hospital and Medical Research Center, Tampa, FL 33612
Subhra Mohapatra, PhD: Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center, Tampa, FL 33612; Department of Molecular Medicine, Tampa, FL 33612; University of South Florida College of Medicine, and James A. Haley VA Hospital and Medical Research Center, Tampa, FL 33612; Corresponding author.
Shyam Mohapatra, PhD: Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center, Tampa, FL 33612; Division of Allergy and Immunology, Tampa, FL 33612; University of South Florida College of Medicine, and James A. Haley VA Hospital and Medical Research Center, Tampa, FL 33612

Journal volume & issue: Vol. 4, no. 6
pp. 94 – 103

Abstract

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One obstacle to developing an effective therapeutic strategy to treat or prevent asthma is that the fundamental causes of asthma are not totally understood. Asthma is thought to be a chronic TH2 immune-mediated inflammatory disease. Epigenetic changes are recognized to play a role in the initiation and maintenance of a TH2 response. MicroRNAs (miRNAs) are key epigenetic regulators of gene expression, and their expression is highly regulated, therefore, deregulation of miRNAs may play an important role in the pathogenesis of asthma. Profiling circulating miRNA might provide the highest specificity and sensitivity to diagnose asthma; similarly, correcting potential defects in the miRNA regulation network may lead to new therapeutic modalities to treat this disease. Keywords: microRNA, circulating, epigenetics, asthma, biomarkers

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

About the journal