Nature Communications (Oct 2017)
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
- Peter K. Joshi,
- Nicola Pirastu,
- Katherine A. Kentistou,
- Krista Fischer,
- Edith Hofer,
- Katharina E. Schraut,
- David W. Clark,
- Teresa Nutile,
- Catriona L. K. Barnes,
- Paul R. H. J. Timmers,
- Xia Shen,
- Ilaria Gandin,
- Aaron F. McDaid,
- Thomas Folkmann Hansen,
- Scott D. Gordon,
- Franco Giulianini,
- Thibaud S. Boutin,
- Abdel Abdellaoui,
- Wei Zhao,
- Carolina Medina-Gomez,
- Traci M. Bartz,
- Stella Trompet,
- Leslie A. Lange,
- Laura Raffield,
- Ashley van der Spek,
- Tessel E. Galesloot,
- Petroula Proitsi,
- Lisa R. Yanek,
- Lawrence F. Bielak,
- Antony Payton,
- Federico Murgia,
- Maria Pina Concas,
- Ginevra Biino,
- Salman M. Tajuddin,
- Ilkka Seppälä,
- Najaf Amin,
- Eric Boerwinkle,
- Anders D. Børglum,
- Archie Campbell,
- Ellen W. Demerath,
- Ilja Demuth,
- Jessica D. Faul,
- Ian Ford,
- Alessandro Gialluisi,
- Martin Gögele,
- MariaElisa Graff,
- Aroon Hingorani,
- Jouke-Jan Hottenga,
- David M. Hougaard,
- Mikko A. Hurme,
- M. Arfan Ikram,
- Marja Jylhä,
- Diana Kuh,
- Lannie Ligthart,
- Christina M. Lill,
- Ulman Lindenberger,
- Thomas Lumley,
- Reedik Mägi,
- Pedro Marques-Vidal,
- Sarah E. Medland,
- Lili Milani,
- Reka Nagy,
- William E. R. Ollier,
- Patricia A. Peyser,
- Peter P. Pramstaller,
- Paul M. Ridker,
- Fernando Rivadeneira,
- Daniela Ruggiero,
- Yasaman Saba,
- Reinhold Schmidt,
- Helena Schmidt,
- P. Eline Slagboom,
- Blair H. Smith,
- Jennifer A. Smith,
- Nona Sotoodehnia,
- Elisabeth Steinhagen-Thiessen,
- Frank J. A. van Rooij,
- André L. Verbeek,
- Sita H. Vermeulen,
- Peter Vollenweider,
- Yunpeng Wang,
- Thomas Werge,
- John B. Whitfield,
- Alan B. Zonderman,
- Terho Lehtimäki,
- Michele K. Evans,
- Mario Pirastu,
- Christian Fuchsberger,
- Lars Bertram,
- Neil Pendleton,
- Sharon L. R. Kardia,
- Marina Ciullo,
- Diane M. Becker,
- Andrew Wong,
- Bruce M. Psaty,
- Cornelia M. van Duijn,
- James G. Wilson,
- J. Wouter Jukema,
- Lambertus Kiemeney,
- André G. Uitterlinden,
- Nora Franceschini,
- Kari E. North,
- David R. Weir,
- Andres Metspalu,
- Dorret I. Boomsma,
- Caroline Hayward,
- Daniel Chasman,
- Nicholas G. Martin,
- Naveed Sattar,
- Harry Campbell,
- Tōnu Esko,
- Zoltán Kutalik,
- James F. Wilson
Affiliations
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Nicola Pirastu
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Katherine A. Kentistou
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Krista Fischer
- Estonian Genome Center, University of Tartu, University of Tartu
- Edith Hofer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Katharina E. Schraut
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- David W. Clark
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Teresa Nutile
- Institute of Genetics and Biophysics “A. Buzzati-Traverso” - CNR
- Catriona L. K. Barnes
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Paul R. H. J. Timmers
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Xia Shen
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Ilaria Gandin
- Department of Medical Sciences, University of Trieste
- Aaron F. McDaid
- Institute of Social and Preventive Medicine, Lausanne University Hospital
- Thomas Folkmann Hansen
- Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen
- Scott D. Gordon
- QIMR Berghofer Institute of Medical Research
- Franco Giulianini
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Thibaud S. Boutin
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Abdel Abdellaoui
- Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH)
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Carolina Medina-Gomez
- Department of Internal Medicine, Erasmus University Medical Center
- Traci M. Bartz
- Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington
- Stella Trompet
- Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center
- Leslie A. Lange
- Department of Medicine, University of Colorado Denver, Anschutz Medical Campus
- Laura Raffield
- Department of Genetics, University of North Carolina
- Ashley van der Spek
- Department of Epidemiology, Erasmus University Medical Center
- Tessel E. Galesloot
- Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center
- Petroula Proitsi
- MRC Unit for Lifelong Health & Ageing at UCL, University College London
- Lisa R. Yanek
- Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Antony Payton
- Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester
- Federico Murgia
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany)
- Maria Pina Concas
- Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy
- Ginevra Biino
- Institute of Molecular Genetics, National Research Council of Italy
- Salman M. Tajuddin
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Ilkka Seppälä
- Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere
- Najaf Amin
- Department of Epidemiology, Erasmus University Medical Center
- Eric Boerwinkle
- Health Science Center at Houston, UTHealth School of Public Health, University of Texas
- Anders D. Børglum
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Archie Campbell
- Centre for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ellen W. Demerath
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- Ilja Demuth
- Charité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Ian Ford
- Robertson Center for biostatistics, University of Glasgow
- Alessandro Gialluisi
- IRCCS Neuromed
- Martin Gögele
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany)
- MariaElisa Graff
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Aroon Hingorani
- Institute of Cardiovascular Science, University College London
- Jouke-Jan Hottenga
- Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH)
- David M. Hougaard
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Mikko A. Hurme
- Department of Microbiology and Immunology, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Marja Jylhä
- Gerontology Research Center, Tampere, Finland, Faculty of Social Sciences, University of Tampere
- Diana Kuh
- MRC Unit for Lifelong Health & Ageing at UCL, University College London
- Lannie Ligthart
- Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH)
- Christina M. Lill
- Genetic and Molecular Epidemiology Group, Institute of Neurogenetics, University of Lübeck
- Ulman Lindenberger
- Center for Lifespan Psychology, Max Planck Institute for Human Development
- Thomas Lumley
- Department of Statistics, University of Auckland
- Reedik Mägi
- Estonian Genome Center, University of Tartu, University of Tartu
- Pedro Marques-Vidal
- Department of Medicine, Internal Medicine, Lausanne University Hospital
- Sarah E. Medland
- QIMR Berghofer Institute of Medical Research
- Lili Milani
- Estonian Genome Center, University of Tartu, University of Tartu
- Reka Nagy
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- William E. R. Ollier
- Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Peter P. Pramstaller
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany)
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus University Medical Center
- Daniela Ruggiero
- Institute of Genetics and Biophysics “A. Buzzati-Traverso” - CNR
- Yasaman Saba
- Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz
- Reinhold Schmidt
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Helena Schmidt
- Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz
- P. Eline Slagboom
- Section of Molecular Epidemiology, Department of medical statistics, Leiden University Medical Center
- Blair H. Smith
- Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Elisabeth Steinhagen-Thiessen
- Charité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin
- Frank J. A. van Rooij
- Department of Epidemiology, Erasmus University Medical Center
- André L. Verbeek
- Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center
- Sita H. Vermeulen
- Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center
- Peter Vollenweider
- Department of Medicine, Internal Medicine, Lausanne University Hospital
- Yunpeng Wang
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Thomas Werge
- Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen
- John B. Whitfield
- QIMR Berghofer Institute of Medical Research
- Alan B. Zonderman
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere
- Michele K. Evans
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Mario Pirastu
- Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy
- Christian Fuchsberger
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany)
- Lars Bertram
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck
- Neil Pendleton
- Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Marina Ciullo
- Institute of Genetics and Biophysics “A. Buzzati-Traverso” - CNR
- Diane M. Becker
- Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Andrew Wong
- MRC Unit for Lifelong Health & Ageing at UCL, University College London
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, University of Washington
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus University Medical Center
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Lambertus Kiemeney
- Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center
- Nora Franceschini
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- David R. Weir
- Survey Research Center, Institute for Social Research, University of Michigan
- Andres Metspalu
- Estonian Genome Center, University of Tartu, University of Tartu
- Dorret I. Boomsma
- Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH)
- Caroline Hayward
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Daniel Chasman
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Nicholas G. Martin
- QIMR Berghofer Institute of Medical Research
- Naveed Sattar
- BHF Glasgow Cardiovascular Research Centre, University of Glasgow
- Harry Campbell
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Tōnu Esko
- Estonian Genome Center, University of Tartu, University of Tartu
- Zoltán Kutalik
- Institute of Social and Preventive Medicine, Lausanne University Hospital
- James F. Wilson
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-017-00934-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.
