Communications Biology (Jan 2021)

Fractional re-distribution among cell motility states during ageing

  • Jude M. Phillip,
  • Nahuel Zamponi,
  • Madonna P. Phillip,
  • Jena Daya,
  • Shaun McGovern,
  • Wadsworth Williams,
  • Katherine Tschudi,
  • Hasini Jayatilaka,
  • Pei-Hsun Wu,
  • Jeremy Walston,
  • Denis Wirtz

DOI
https://doi.org/10.1038/s42003-020-01605-w
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 9

Abstract

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Phillip and colleagues use dermal fibroblasts from a range of donors to quantify cell motility in ageing cells. They show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional redistribution among motility states.