Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias

• Dominic J. Fowler-Shorten,
• Rebecca S. Maynard,
• Katherine Hampton,
• Annalisa Altera,
• Matthew Markham,
• Martha Ehikioya,
• Edyta E. Wojtowicz,
• Kristian M. Bowles,
• Stuart A. Rushworth,
• Charlotte Hellmich

Affiliations

Dominic J. Fowler-Shorten

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Rebecca S. Maynard

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Katherine Hampton

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Annalisa Altera

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Matthew Markham

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Martha Ehikioya

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Edyta E. Wojtowicz

Earlham Institute, Norwich Research Park, Norwich, NR4 7UH

Kristian M. Bowles

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY

Stuart A. Rushworth

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ

Charlotte Hellmich

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY