Nature Communications (Jul 2019)
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
- Esmee Koedoot,
- Michiel Fokkelman,
- Vasiliki-Maria Rogkoti,
- Marcel Smid,
- Iris van de Sandt,
- Hans de Bont,
- Chantal Pont,
- Janna E. Klip,
- Steven Wink,
- Mieke A. Timmermans,
- Erik A. C. Wiemer,
- Peter Stoilov,
- John A. Foekens,
- Sylvia E. Le Dévédec,
- John W. M. Martens,
- Bob van de Water
Affiliations
- Esmee Koedoot
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Michiel Fokkelman
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Vasiliki-Maria Rogkoti
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Marcel Smid
- Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Iris van de Sandt
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Hans de Bont
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Chantal Pont
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Janna E. Klip
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Steven Wink
- Division of Drug Discovery and Safety, LACDR, Leiden University
- Mieke A. Timmermans
- Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Erik A. C. Wiemer
- Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Peter Stoilov
- Department of Biochemistry and Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University
- John A. Foekens
- Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Sylvia E. Le Dévédec
- Division of Drug Discovery and Safety, LACDR, Leiden University
- John W. M. Martens
- Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Bob van de Water
- Division of Drug Discovery and Safety, LACDR, Leiden University
- DOI
- https://doi.org/10.1038/s41467-019-11020-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators, PRPF4B, mediates metastasis in TNBC in mice.
