Four New Dicaffeoylquinic Acid Derivatives from Glasswort (Salicornia herbacea L.) and Their Antioxidative Activity
Jeong-Yong Cho,
Jin Young Kim,
Yu Geon Lee,
Hyoung Jae Lee,
Hyun Jeong Shim,
Ji Hye Lee,
Seon-Jae Kim,
Kyung-Sik Ham,
Jae-Hak Moon
Affiliations
Jeong-Yong Cho
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Jin Young Kim
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Yu Geon Lee
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Hyoung Jae Lee
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Hyun Jeong Shim
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Ji Hye Lee
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Seon-Jae Kim
Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Korea
Kyung-Sik Ham
Department of Food Engineering and Solar Salt Research Center, Mokpo National University, Jeonnam 58554, Korea
Jae-Hak Moon
Department of Food Science and Technology and Functional Food Research Center, BK21 Plus Program, and Chonnam National University, Gwangju 61186, Korea
Four new dicaffeoylquinic acid derivatives and two known 3-caffeoylquinic acid derivatives were isolated from methanol extracts using the aerial parts of Salicornia herbacea. The four new dicaffeoylquinic acid derivatives were established as 3-caffeoyl-5-dihydrocaffeoylquinic acid, 3-caffeoyl-5-dihydrocaffeoylquinic acid methyl ester, 3-caffeoyl-4-dihydrocaffeoylquinic acid methyl ester, and 3,5-di-dihydrocaffeoylquinic acid methyl ester. Their chemical structures were determined by nuclear magnetic resonance and electrospray ionization-mass spectroscopy (LC-ESI-MS). In addition, the presence of dicaffeoylquinic acid derivatives in this plant was reconfirmed by LC-ESI-MS/MS analysis. The isolated compounds strongly scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited cholesteryl ester hydroperoxide formation during rat blood plasma oxidation induced by copper ions. These results indicate that the caffeoylquinic acid derivatives may partially contribute to the antioxidative effect of S. herbacea.
