The state of rat gastric mucosa under the influence of cytostatics: dihydropyrrol derivative, 5-fluorouracil and their combination

Abstract

In vivo studies of dihydropyrrol derivative 5-amino-4-(1,3-benzothiazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3Н-pyrrol-3-one (D1) impact on rat gastric mucosa compared with 5-fluorouracil were performed. D1 causes the local desquamation of surface epithelium and focal submucosa lympho-histiocytary infiltration and stimulates the compensatory-adaptive processes. In contrast, 5-fluorouracil causes significant desquamation of epithelium, gastric gland destruction and surface stratification, sometimes epithelium dystrophy with necrotic foci, and inhibits the mucosa functional activity. D1 under concomitant action with 5-fluorouracil reduces the toxic effect of 5-fluorouracil on gastric mucosa, resulting in less expressed inflammation and destructive changes and partial recovery of gastric mucosa morpho-functional state. Coordinated response of gastric mucosa structural elements to the action of investigated compounds was observed.

Keywords

• dihydropyrrol derivative
• 5-fluorouracil
• gastric mucosa