A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

Hongwei Lu; An Chen; Xindan Zhang; Zixiang Wei; Rong Cao; Yi Zhu; Jingxiong Lu; Zhongling Wang; Leilei Tian

doi:10.1038/s41467-022-35655-x

Nature Communications (Dec 2022)

A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

Hongwei Lu,
An Chen,
Xindan Zhang,
Zixiang Wei,
Rong Cao,
Yi Zhu,
Jingxiong Lu,
Zhongling Wang,
Leilei Tian

Affiliations

Hongwei Lu: Department of Materials Science and Engineering, Southern University of Science and Technology
An Chen: Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University
Xindan Zhang: Department of Materials Science and Engineering, Southern University of Science and Technology
Zixiang Wei: Department of Materials Science and Engineering, Southern University of Science and Technology
Rong Cao: Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University
Yi Zhu: Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University
Jingxiong Lu: Department of Materials Science and Engineering, Southern University of Science and Technology
Zhongling Wang: Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University
Leilei Tian: Department of Materials Science and Engineering, Southern University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-35655-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Magnetic resonance imaging (MRI) is a well-established non-invasive medical imaging technology. Here, to improve the performance of the technique, the authors describe the design of a pH-responsive T1-T2 dual-modal MRI contrast agent, showing enhanced imaging sensitivity in preclinical cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal