NeuroImage (Jan 2025)
Neurostructural correlates of harm action/outcome aversion: The role of empathy
Abstract
Harm aversion is essential for normal human functioning; however, the neuroanatomical mechanisms underlying harm aversion remain unclear. To explore this issue, we examined the brain structures associated with the two distinct dimensions of harm aversion (harm action/outcome aversion) and the potential mediating role of the four aspects of empathy: fantasy, perspective-taking, empathic concern, and personal distress. A sample of 214 healthy young adults underwent structural magnetic resonance imaging. Voxel-based morphometry was used to assess regional gray matter volume (rGMV) and regional gray matter density (rGMD). Whole-brain multiple regression analysis revealed significant correlations between harm action aversion and rGMV/rGMD in various brain regions, including the inferior frontal gyrus (IFG) and precuneus for both rGMV and rGMD, the cerebellum for rGMV, and the superior frontal gyrus for rGMD. The rGMV/rGMD in the IFG and the rGMD in the primary somatosensory cortex (S1) were correlated with harm outcome aversion. Utilizing 10-fold balanced cross-validation analysis, we confirmed the robustness of these significant associations between rGMV/rGMD in these brain regions and harm action/outcome aversion. Importantly, mediation analysis revealed that empathic concern mediated the relationship between rGMV/rGMD in the precuneus and harm action aversion. Additionally, empathic concern, personal distress, and total empathy mediated the relationship between rGMD in the S1 and harm outcome aversion. These findings enhance our understanding of the neural mechanism of harm aversion by integrating insights from the brain structure, harm aversion, and the personality hierarchy models while also extending the frontal asymmetry model of Emotion
