A case of intravascular lymphoma presenting with a lesion in the splenium of the corpus callosum

Haruka Masuzawa, MD; Fumio Suzuki, MD, PhD; Shiori Amemiya, MD, PhD; Kenta Orimo, MD; Hiroyuki Ishiura, MD, PhD; Ryo Hara, MD; Tatsushi Toda, MD, PhD; Teruo Nakazawa, MD; Akira Honda, MD, PhD; Mariko Tanaka, MD, PhD; Munetoshi Hinata, MD, PhD; Osamu Abe, MD, PhD

Radiology Case Reports (May 2023)

A case of intravascular lymphoma presenting with a lesion in the splenium of the corpus callosum

Haruka Masuzawa, MD,
Fumio Suzuki, MD, PhD,
Shiori Amemiya, MD, PhD,
Kenta Orimo, MD,
Hiroyuki Ishiura, MD, PhD,
Ryo Hara, MD,
Tatsushi Toda, MD, PhD,
Teruo Nakazawa, MD,
Akira Honda, MD, PhD,
Mariko Tanaka, MD, PhD,
Munetoshi Hinata, MD, PhD,
Osamu Abe, MD, PhD

Affiliations

Haruka Masuzawa, MD: Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan; Corresponding author.
Fumio Suzuki, MD, PhD: Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan
Shiori Amemiya, MD, PhD: Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan
Kenta Orimo, MD: Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, BunkyoCity, Tokyo, 113-8655, Japan
Hiroyuki Ishiura, MD, PhD: Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, BunkyoCity, Tokyo, 113-8655, Japan
Ryo Hara, MD: Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan
Tatsushi Toda, MD, PhD: Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, BunkyoCity, Tokyo, 113-8655, Japan
Teruo Nakazawa, MD: Department of Neurology, Kashiwa Kousei General Hospital, 617 Shikoda, Kashiwa-shi, Chiba-ken 277-8551, Japan
Akira Honda, MD, PhD: Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan
Mariko Tanaka, MD, PhD: Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan
Munetoshi Hinata, MD, PhD: Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan
Osamu Abe, MD, PhD: Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo City, Tokyo, 113-8655, Japan

Journal volume & issue: Vol. 18, no. 5
pp. 1929 – 1932

Abstract

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Intravascular lymphoma (IVL) is difficult to diagnose because its clinical presentation and laboratory and imaging findings are nonspecific. Herein, we report a case of IVL presenting as a lesion in the splenium of the corpus callosum. A 52-year-old man attended the emergency department with a 2-week history of progressively worsening abnormal behavior and gait disturbance. Magnetic resonance imaging on admission revealed an oval lesion in the splenium of the corpus callosum. The follow-up magnetic resonance imaging performed 2 months after disease onset revealed multiple high-signal areas in the bilateral cerebral white matter on T2-weighted images and diffusion-weighted images. The blood test results showed an elevated level of lactate dehydrogenase and serum-soluble interleukin-2 receptor. These findings were compatible with the diagnosis of IVL. IVL is often difficult to diagnose due to a wide variety of clinical presentations and imaging findings.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: http://www.journals.elsevier.com/radiology-case-reports/

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