Understanding the relationship between circulating platelets and epithelial to mesenchymal transition – a step towards in discovering new epithelial ovarian cancer targeted therapies

Abstract

In the last decades understanding the relationship between the circulating platelets and the biological aggressivity of ovarian cancer gave the opportunity to researchers to introduce new therapeutic lines in ovarian cancer patients with promising results. Therefore, this subject has become intensively studied and surprising correlation ships have been observed. One of the most recently investigated issues regards the influence of circulating platelets on epithelial ovarian cancer refers to the platelets’ ability to induce the epithelial to mesenchymal transition. The current paper aims to discuss about this subject and about the clinical implications of the process.

Keywords

• epithelial to mesenchymal transition
• ovarian cancer
• platelets