Modeling amperometric biosensors based on allosteric enzymes

Computational Science and Techniques. 2013;1(2):205-213 DOI 10.15181/csat.v1i2.79


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Journal Title: Computational Science and Techniques

ISSN: 2029-9966 (Online)

Publisher: Klaipeda University

Society/Institution: Klaipeda University

LCC Subject Category: Science: Mathematics: Instruments and machines: Electronic computers. Computer science

Country of publisher: Lithuania

Language of fulltext: English, Lithuanian

Full-text formats available: PDF



Liutauras Ričkus (Vilnius University)


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 20 weeks


Abstract | Full Text

<p>Computational modeling of a biosensor with allosteric enzyme layer was investigated in this study. The operation of the biosensor is modeled using non-stationary reaction-diffusion equations. The model involves three regions: the allosteric enzyme layer where the allosteric enzyme reactions as well as then mass transport by diffusion take place, the diffusion region where the mass transport by diffusion and non-enzymatic reactions take place and the convective region in which the analyte concentration is maintained constant. The biosensor response on dependency substrate concentration, cooperativity coefficient and the diffusion layer thickness on the same parameters have been studied.</p>