Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

Elliot Stieglitz; Tali Mazor; Adam B. Olshen; Huimin Geng; Laura C. Gelston; Jon Akutagawa; Daniel B. Lipka; Christoph Plass; Christian Flotho; Farid F. Chehab; Benjamin S. Braun; Joseph F. Costello; Mignon L. Loh

doi:10.1038/s41467-017-02178-9

Nature Communications (Dec 2017)

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

Elliot Stieglitz,
Tali Mazor,
Adam B. Olshen,
Huimin Geng,
Laura C. Gelston,
Jon Akutagawa,
Daniel B. Lipka,
Christoph Plass,
Christian Flotho,
Farid F. Chehab,
Benjamin S. Braun,
Joseph F. Costello,
Mignon L. Loh

Affiliations

Elliot Stieglitz: Department of Pediatrics, Benioff Children’s Hospital, University of California, San Francisco
Tali Mazor: Department of Neurological Surgery, University of California, San Francisco
Adam B. Olshen: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
Huimin Geng: Departments of Laboratory Medicine and Cellular and Molecular Pharmacology, University of California
Laura C. Gelston: Department of Pediatrics, Benioff Children’s Hospital, University of California, San Francisco
Jon Akutagawa: Department of Pediatrics, Benioff Children’s Hospital, University of California, San Francisco
Daniel B. Lipka: Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
Christoph Plass: Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)
Christian Flotho: German Cancer Consortium (DKTK), Im Neuenheimer Feld 280
Farid F. Chehab: Department of Laboratory Medicine, University of California, San Francisco
Benjamin S. Braun: Department of Pediatrics, Benioff Children’s Hospital, University of California, San Francisco
Joseph F. Costello: Department of Neurological Surgery, University of California, San Francisco
Mignon L. Loh: Department of Pediatrics, Benioff Children’s Hospital, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-017-02178-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors utilize DNA methylation based subgroups in JMML to predict clinical outcome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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