Sympathectomized tumor-bearing mice survive longer but develop bigger melanomas

Abstract

Objectives. Previously we have shown that 20 days after the tumor cells injection smaller melanomas have been developed in chemically sympathectomized mice in comparison with animals having intact sympathetic nervous system. However, it is known that chemical sympathectomy reduces the sympathetic neurotransmission only temporarily. In the present study, we monitored the survival of the sympathectomized mice with melanoma with an attempt to find out how long the suppressing effect of sympathectomy on the melanoma growth may endure.

Keywords

• 6-hydroxydopamine
• b16-f10 melanoma cells
• melanoma development and growth
• tumor weight