Protective effect of Hydroalcoholic Extract of Nasturtium Officinalis Against Carbon Tetrachloride-Induced Liver Damage in Rats

Abstract

Abstract: Background and aim: Leaves and flowers of Nasturtium officinalis L. contain flavonoid compounds. This plant has several characteristics, such as anticancer properties, blood suger insucer and blood lipids. In the present study, the protective effect of hydroalcoholic extract of grasses in liver toxicity induced by carbon tetrachloride in Wistar rats was investigated.   Methods: In this research, 32 male Wistar rats were randomly allocated into four equal groups of  control (received olive Oil), positive control (received olive Oil + CCl4), and four groups as treatment 1 and 2 received olive oil intraperitoneal administration and 250, 500mg/kg body weight hydroalcoholic extract Nastartium officinals respectively. Animals were treated orally by gavage daily for 32 days. At the end of experiment, serum levels of aspartate and alanine transferase, alkaline phosphatase and total proteins were assessed. The Data was analyzed with using of one-way ANOVA, followed by Tukey's HSD tests using SPSS 21.   Results: The mean of ALT, AST, ALP reduced and total protein increased significantly in the in the fourth group compared to the second group (P<0.05). Histological investigation demonstrated that necrosis and inflammation of liver reduced following carbon tetrachloride (CCl4)-induced hepatotoxicity.   Conclusion: Hydroalcoholic extract of Nasturtium officinal's can protect liver cells against toxic oxidative damage caused by carbon tetrachloride.    

Keywords

• Nasturtium officinalis
• Carbon tetrachloride
• Liver toxicity
• Rat