Molecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems

Jingpeng Zhu; Yina Gao; Yong Wang; Qi Zhan; Han Feng; Xiu Luo; Peipei Li; Songqing Liu; Hai Hou; Pu Gao

doi:10.1038/s41467-022-34085-z

Nature Communications (Oct 2022)

Molecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems

Jingpeng Zhu,
Yina Gao,
Yong Wang,
Qi Zhan,
Han Feng,
Xiu Luo,
Peipei Li,
Songqing Liu,
Hai Hou,
Pu Gao

Affiliations

Jingpeng Zhu: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yina Gao: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yong Wang: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Qi Zhan: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Han Feng: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiu Luo: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Peipei Li: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Songqing Liu: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Hai Hou: Institute of Medical Research, Northwestern Polytechnical University
Pu Gao: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-34085-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Type I R-M systems help establish the prokaryotic DNA methylation landscape and provide protection against invasive DNA. Here, the authors report on detailed structural and molecular mechanisms of a non-canonical type I R-M methyltransferase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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