Comparative mathematical analysis of the colony-forming ability of bone marrow of mice irradiated in lethal dose with high and low dose rate

Abstract

Using (1) original mathematical model, (2) new scheme of hematopoiesis and experimental results of γ-irradiation influence in the dose of 8 Gy with 5 and 0.0028 Gy/min dose rate on the number of colony-forming units (CFU) of bone marrow (BM), as well as (3) experimental data concerning the reparation processes of BM CFU, obtained from the scientific publications, we determine parameters characterizing the reaction of hematopoietic system on the different stages of reparation processes of BM CFU number after the termination of ionizing radiation action.

Keywords

• ionizing radiation
• lethal dose
• bone marrow
• functional properties