Predictive factors of platelet increase and complications after percutaneous trans-arterial partial splenic embolization for hypersplenism in chronic liver disease patients

Abstract

Purpose: To identify predictive factors for platelets normalization and major complications associated with partial splenic embolization (PSE) in patients with chronic liver disease and hypersplenism. Methods and materials: A prospective study included 30 patients were subjected to pre-embolization abdominal US and laboratory testing (WBC, Hemoglobin, Platelet Count, T. Bilirubin, AST, ALT, S. Albumin). PSE were done by super-selective catheterization of splenic artery and embolization by Polyvinyl alcohol with targeted therapeutic splenic infarction rate (>30% to 8 remained significant predictors for major complication (p = 0.035). Conclusion: Platelet count normalization could be achieved by increasing infraction rate to 67–76%. Child Score and serum albumin are the predictive factor for complications.

Keywords

• Partial Splenic Embolization (PSE)
• Polyvinyl alcohol (PVA)
• Platelet count increase
• Hypersplenism
• Infarction rate