Nature Communications (Jun 2019)
The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
Abstract
Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cells, p16Ink4a accumulates, causing regenerative defects.