Nature Communications (Apr 2021)

A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis

  • Kai Biao Wang,
  • Wen Wang,
  • Bo Zhang,
  • Xin Wang,
  • Yu Chen,
  • Hong Jie Zhu,
  • Yong Liang,
  • Ren Xiang Tan,
  • Hui Ming Ge

DOI
https://doi.org/10.1038/s41467-021-22395-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Streptoseomycin is a potent antibiotic that contains a pentacyclic 5/14/10/6/6 ring system. Here, the authors report the enzymatic and non-enzymatic steps of the downstream modification of streptoseomycin biosynthesis and show a [6 + 4]-cycloaddition adduct as an unexpected biosynthetic intermediate.