Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

Nighat Noureen; Shaofang Wu; Yingli Lv; Juechen Yang; W. K. Alfred Yung; Jonathan Gelfond; Xiaojing Wang; Dimpy Koul; Andrew Ludlow; Siyuan Zheng

doi:10.1038/s41467-020-20474-9

Nature Communications (Jan 2021)

Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation

Nighat Noureen,
Shaofang Wu,
Yingli Lv,
Juechen Yang,
W. K. Alfred Yung,
Jonathan Gelfond,
Xiaojing Wang,
Dimpy Koul,
Andrew Ludlow,
Siyuan Zheng

Affiliations

Nighat Noureen: Greehey Children’s Cancer Research Institute, UT Health San Antonio
Shaofang Wu: Department of Neuro-Oncology, MD Anderson Cancer Center
Yingli Lv: Greehey Children’s Cancer Research Institute, UT Health San Antonio
Juechen Yang: Greehey Children’s Cancer Research Institute, UT Health San Antonio
W. K. Alfred Yung: Department of Neuro-Oncology, MD Anderson Cancer Center
Jonathan Gelfond: Department of Population Health Sciences, UT Health San Antonio
Xiaojing Wang: Greehey Children’s Cancer Research Institute, UT Health San Antonio
Dimpy Koul: Department of Neuro-Oncology, MD Anderson Cancer Center
Andrew Ludlow: Department of Movement Science, University of Michigan
Siyuan Zheng: Greehey Children’s Cancer Research Institute, UT Health San Antonio

DOI: https://doi.org/10.1038/s41467-020-20474-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell proliferation and stemness.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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