Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case

Abstract

Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) is a rare, aggressive neoplasm thought to originate from the prostatic urethral urothelium. Our case is the first reported to show significantly increased serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in MPUAP. An autopsy revealed occult MPUAP with prominent seminal vesicle, perineural, lymphatic vessel, and vascular invasion and extensive bone metastases. Duration of survival in this case was far shorter than average, and extensive bone metastases were rare in previously reported cases. This suggests serum CEA and CA19-9 levels can be an important prognostic factor in MPUAP. Keywords: Mucin-producing urothelial-type adenocarcinoma of prostate, Carcinoembryonic antigen, Carbohydrate antigen 19-9, Prostate-specific antigen