Journal of Microbiology, Immunology and Infection (Aug 2019)
Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
- María J. Ruiz-de-León,
- María A. Jiménez-Sousa,
- Santiago Moreno,
- Marcial García,
- Mónica Gutiérrez-Rivas,
- Agathe León,
- Marta Montero-Alonso,
- Juan González-García,
- Salvador Resino,
- Norma Rallón,
- José M. Benito,
- Alejandro Vallejo,
- J.M. Benito,
- N. Rallón,
- C. Restrepo,
- N. Rodríguez,
- M. García,
- A. Cabello,
- M. Gorgolas,
- S. Resino,
- V. Briz,
- M.A. Jiménez,
- M.S. Vázquez,
- A. Fernández,
- P. García,
- M.A. Muñoz,
- J. Sánchez,
- J.L. Jiménez,
- D. Sepúlveda,
- I. García,
- I. Consuegra,
- A. León,
- M. Arnedo,
- M. Plana,
- N. Climent,
- F. García,
- E. Ruiz-Mateos,
- B. Domínguez,
- L. Tarancón,
- M. Rafii-El-Idrissi,
- M.J. Polaino,
- M. Genebat,
- P. Viciana,
- M. Leal,
- F. Vidal,
- E. Rodríguez,
- C. Viladés,
- J. Peraire,
- J. Romero,
- C Rodríguez,
- M. Vera,
- J. Esté,
- E. Ballana,
- M.A. Martínez,
- S. Franco,
- M. Nevot,
- A. Vallejo,
- S. Moreno,
- M. Pernas,
- C. Casado,
- C. López,
- L. Capa,
- M. Pérez,
- J. Alcami,
- R. Sanjuán,
- J.M. Cueva,
- R. Delgado,
- O. Sierra,
- A. Valenzuela
Affiliations
- María J. Ruiz-de-León
- Laboratory of Molecular Immunology, Department of Infectious Diseases, Instituto Ramón y Cajal Health Research Institute (IRyCIS), Ramón y Cajal University Hospital, Madrid, Spain
- María A. Jiménez-Sousa
- Viral Infection and Immunity Unit, National Center of Microbiology, Carlos III Health Institute, Majadahonda, Spain
- Santiago Moreno
- Laboratory of Molecular Immunology, Department of Infectious Diseases, Instituto Ramón y Cajal Health Research Institute (IRyCIS), Ramón y Cajal University Hospital, Madrid, Spain
- Marcial García
- IIS-Jiménez Díaz Foundation, UAM, Madrid, Spain; Rey Juan Carlos University Hospital, Móstoles, Madrid, Spain
- Mónica Gutiérrez-Rivas
- Viral Infection and Immunity Unit, National Center of Microbiology, Carlos III Health Institute, Majadahonda, Spain
- Agathe León
- Clinic Hospital-IDIBAPS, HIVACAT, Barcelona University, Barcelona, Spain
- Marta Montero-Alonso
- Infectious Diseases Unit, La Fe University Hospital, Valencia, Spain
- Juan González-García
- Internal Medicine Department, La Paz University Hospital, Madrid, Spain
- Salvador Resino
- Viral Infection and Immunity Unit, National Center of Microbiology, Carlos III Health Institute, Majadahonda, Spain
- Norma Rallón
- IIS-Jiménez Díaz Foundation, UAM, Madrid, Spain; Rey Juan Carlos University Hospital, Móstoles, Madrid, Spain; Corresponding author. IIS-Jiménez Díaz Foundation, UAM, Av. Reyes Católicos, 2, Madrid, 28040, Spain. Fax: +34 91 550 48 49.
- José M. Benito
- IIS-Jiménez Díaz Foundation, UAM, Madrid, Spain; Rey Juan Carlos University Hospital, Móstoles, Madrid, Spain
- Alejandro Vallejo
- Laboratory of Molecular Immunology, Department of Infectious Diseases, Instituto Ramón y Cajal Health Research Institute (IRyCIS), Ramón y Cajal University Hospital, Madrid, Spain; Corresponding author. Laboratory of Molecular Immunovirology, Department of Infectious Diseases, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Ctra Colmenar Km 9, 28034, Madrid, Spain.
- J.M. Benito
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- N. Rallón
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- C. Restrepo
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- N. Rodríguez
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- M. García
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- A. Cabello
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- M. Gorgolas
- IS-Fundación Jimenez Díaz, UAM, Madrid, Spain
- S. Resino
- Instituto Salud Carlos III, Madrid, Spain
- V. Briz
- Instituto Salud Carlos III, Madrid, Spain
- M.A. Jiménez
- Instituto Salud Carlos III, Madrid, Spain
- M.S. Vázquez
- Instituto Salud Carlos III, Madrid, Spain
- A. Fernández
- Instituto Salud Carlos III, Madrid, Spain
- P. García
- Instituto Salud Carlos III, Madrid, Spain
- M.A. Muñoz
- Hospital Gregorio Marañón, Madrid, Spain
- J. Sánchez
- Hospital Gregorio Marañón, Madrid, Spain
- J.L. Jiménez
- Hospital Gregorio Marañón, Madrid, Spain
- D. Sepúlveda
- Hospital Gregorio Marañón, Madrid, Spain
- I. García
- Hospital Gregorio Marañón, Madrid, Spain
- I. Consuegra
- Hospital Gregorio Marañón, Madrid, Spain
- A. León
- Hospital Clinic, Barcelona, Spain
- M. Arnedo
- Hospital Clinic, Barcelona, Spain
- M. Plana
- Hospital Clinic, Barcelona, Spain
- N. Climent
- Hospital Clinic, Barcelona, Spain
- F. García
- Hospital Clinic, Barcelona, Spain
- E. Ruiz-Mateos
- Hospital Virgen del Rocio, Sevilla, Spain
- B. Domínguez
- Hospital Virgen del Rocio, Sevilla, Spain
- L. Tarancón
- Hospital Virgen del Rocio, Sevilla, Spain
- M. Rafii-El-Idrissi
- Hospital Virgen del Rocio, Sevilla, Spain
- M.J. Polaino
- Hospital Virgen del Rocio, Sevilla, Spain
- M. Genebat
- Hospital Virgen del Rocio, Sevilla, Spain
- P. Viciana
- Hospital Virgen del Rocio, Sevilla, Spain
- M. Leal
- Hospital Virgen del Rocio, Sevilla, Spain
- F. Vidal
- Hospital Joan XXIII, Tarragona, Spain
- E. Rodríguez
- Hospital Joan XXIII, Tarragona, Spain
- C. Viladés
- Hospital Joan XXIII, Tarragona, Spain
- J. Peraire
- Hospital Joan XXIII, Tarragona, Spain
- J. Romero
- Centro Sandoval, Madrid, Spain
- C Rodríguez
- Centro Sandoval, Madrid, Spain
- M. Vera
- Centro Sandoval, Madrid, Spain
- J. Esté
- Fundacion IRSI CAIXA, Badalona, Spain
- E. Ballana
- Fundacion IRSI CAIXA, Badalona, Spain
- M.A. Martínez
- Fundacion IRSI CAIXA, Badalona, Spain
- S. Franco
- Fundacion IRSI CAIXA, Badalona, Spain
- M. Nevot
- Fundacion IRSI CAIXA, Badalona, Spain
- A. Vallejo
- Hospital Ramón y Cajal, Madrid, Spain
- S. Moreno
- Hospital Ramón y Cajal, Madrid, Spain
- M. Pernas
- Instituto Salud Carlos III, Madrid, Spain
- C. Casado
- Instituto Salud Carlos III, Madrid, Spain
- C. López
- Instituto Salud Carlos III, Madrid, Spain
- L. Capa
- Instituto Salud Carlos III, Madrid, Spain
- M. Pérez
- Instituto Salud Carlos III, Madrid, Spain
- J. Alcami
- Instituto Salud Carlos III, Madrid, Spain
- R. Sanjuán
- Universidad de Valencia, Spain
- J.M. Cueva
- Universidad de Valencia, Spain
- R. Delgado
- Hospital 12 de Octubre, Madrid, Spain
- O. Sierra
- Hospital 12 de Octubre, Madrid, Spain
- A. Valenzuela
- Universidad de la Laguna, Sta. Cruz Tenerife, Spain
- Journal volume & issue
-
Vol. 52,
no. 4
pp. 667 – 671
Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Keywords: Exosomes, miRNAs, HIV-1, Elite controllers, Immune activation, Soluble biomarkers
