Nature Communications (Feb 2018)

Steric exclusion and protein conformation determine the localization of plasma membrane transporters

  • Frans Bianchi,
  • Łukasz Syga,
  • Gemma Moiset,
  • Dian Spakman,
  • Paul E. Schavemaker,
  • Christiaan M. Punter,
  • Anne-Bart Seinen,
  • Antoine M. van Oijen,
  • Andrew Robinson,
  • Bert Poolman

DOI
https://doi.org/10.1038/s41467-018-02864-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The yeast plasma membrane consists of membrane microdomains with distinct protein composition. Here the authors use high-resolution single molecule imaging to observe diffusion of specific transmembrane proteins in and out of these microdomains, and propose features that dictate their inclusion/exclusion from these structures.