Open Medicine (Apr 2024)

Emerging role and function of SPDL1 in human health and diseases

  • Feng Yuejiao,
  • Tang Donghao,
  • Wang Jie

DOI
https://doi.org/10.1515/med-2024-0922
Journal volume & issue
Vol. 19, no. 1
pp. 52 – 8

Abstract

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SPDL1 (spindle apparatus coiled-coil protein 1), also referred to as CCDC99, is a recently identified gene involved in cell cycle regulation. SPDL1 encodes a protein, hSpindly, which plays a critical role in the maintenance of spindle checkpoint silencing during mitosis. hSpindly coordinates microtubule attachment by promoting kinesin recruitment and mitotic checkpoint signaling. Moreover, the protein performs numerous biological functions in vivo and its aberrant expression is closely associated with abnormal neuronal development, pulmonary interstitial fibrosis, and malignant tumor development. In this review, we provide an overview of studies that reveal the characteristics of SPDL1 and of the protein encoded by it, as well as its biological and tumor-promoting functions.

Keywords