VARIOUS TECHNIQUES FOR THE EVALUATION OF ANTI ARTHRITIC ACTIVITY IN ANIMAL MODELS

Abstract

Arthritis is an auto immune disorder characterized by pain, swelling and stiffness. Its prevalence depends upon age. It occurs more frequently in women than in men. It is an inflammation of synovial joint due to immuno mediated response. All anti inflammatory drugs are not anti arthritic because it does not suppress T-cell and B-cell mediated response. Epidemiological studies overall show a female to male ratio of about 3:1. There are many class of anti-arthritic drugs are available like NSAIDS, Monoclonal anti-bodies, uricosuric agents, gold compounds, anti-cytokinine immunosuppressant like glucocorticoids, etc. But this all class of drugs is responsible for symptomatic relief. To evaluate the drug which actually prevent cause of arthritic or act during various step of arthritis there is requirement of evaluative model which produce arthritis in animal same that produce in humans. Animal models of arthritis are used to study pathogenesis of disease and to evaluate potential anti-arthritic drugs for clinical use. Therefore morphological similarities to human disease and capacity of the model to predict efficacy in humans are important criteria in model selection.

Keywords

• Monoclonal anti-bodies
• uricosuric agents
• gold compounds
• anti-cytokinine immunosuppressant.