Nature Communications (Jun 2019)
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
Abstract
EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer.