Nature Communications (Jun 2019)

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

  • Jie Zhou,
  • Shuo Huang,
  • Zhongyu Wang,
  • Jiani Huang,
  • Liang Xu,
  • Xuefeng Tang,
  • Yisong Y. Wan,
  • Qi-jing Li,
  • Alistair L. J. Symonds,
  • Haixia Long,
  • Bo Zhu

DOI
https://doi.org/10.1038/s41467-019-10176-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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EZH2-mediated methylatation of histone 3 is essential for immune regulation. Here, the authors show that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer.