Nature Communications (Sep 2019)
microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression
- Zhengyi Zhang,
- Jingnan Pi,
- Dongling Zou,
- Xiaoshuang Wang,
- Jiayue Xu,
- Shan Yu,
- Ting Zhang,
- Feng Li,
- Xianxie Zhang,
- Hualu Zhao,
- Fang Wang,
- Dong Wang,
- Yanni Ma,
- Jia Yu
Affiliations
- Zhengyi Zhang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Jingnan Pi
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Dongling Zou
- Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital
- Xiaoshuang Wang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Jiayue Xu
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Shan Yu
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Ting Zhang
- Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University
- Feng Li
- Molecular Biology Laboratory, Shanxi Cancer Hospital
- Xianxie Zhang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Hualu Zhao
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Fang Wang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Dong Wang
- Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University
- Yanni Ma
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- Jia Yu
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC)
- DOI
- https://doi.org/10.1038/s41467-019-12292-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Functional miRNAs derived from the 5p or 3p arm of some miRNA duplexes have opposite roles in cancer progression. Here, the authors show that oncogenic miR-574-5p has greater preference in aggressive gastric cancer as compared with miR-574-3p and this arm preference is partly dependent on complementary targets mediated miRNA decay.
