Long-term prognosis of CHD depends on fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids in patients with acute myocardial infarction

Abstract

To assess influence of the natural fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids (PUFA) in patients with acute myocardial infarction (MI), on coronary heart disease (CRD) progression. Sixty patients, who had MI in 1991-92, were surveyed and included into the main group of EURAMIC study. According to the variants of CHD progression (death, recurrent MI, stroke, myocardial revascularization), all participants were divided into two groups: 25 individuals without CHD progression (Pr-), and another 35 - with CHD progression (Pr+). To study complex influence of traditional CVD risk factors, lipophylic antioxidants and PUFA levels on the long-term prognosis, as well as for assessing the individual input of each variable, multiple regression analysis was used. The results obtained have demonstrated the following: 1. Carotinoid and PUFA levels in fat tissue of acute MI patients did influence the long-term prognosis of CHD. 2. In patients with MI, decreased level of low-density lipoprotein cholesterol was a significant predictor of poor prognosis. 3. In initially normostenic MI patients, further increase in body mass index associated with worse CHD prognosis.

Keywords

• острый инфаркт миокарда
• отдаленный прогноз
• роль липофильных антиоксидантов полиненасыщенных жирных кислот
• ретроспективное исследование