Nature Communications (Oct 2017)

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

  • Ian J. Huggins,
  • Tomas Bos,
  • Olivia Gaylord,
  • Christina Jessen,
  • Brianna Lonquich,
  • Angeline Puranen,
  • Jenna Richter,
  • Charlotte Rossdam,
  • David Brafman,
  • Terry Gaasterland,
  • Karl Willert

DOI
https://doi.org/10.1038/s41467-017-01203-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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WNT/β-catenin signaling is an essential regulator of many developmental processes. Here, the authors provide evidence that activation of the WNT in human pluripotent stem cells leads to expression WNT target gene SP5, which then acts to diminish expression of active WNT target genes.