PLoS ONE (Jan 2013)

A novel electrocardiographic index for the diagnosis of diastolic dysfunction.

  • Mehdi Namdar,
  • Patric Biaggi,
  • Barbara Stähli,
  • Bernhard Bütler,
  • Rubén Casado-Arroyo,
  • Danilo Ricciardi,
  • Moisés Rodríguez-Mañero,
  • Jan Steffel,
  • David Hürlimann,
  • Christian Schmied,
  • Carlo de Asmundis,
  • Gian-Battista Chierchia,
  • Andrea Sarkozy,
  • Thomas F Lüscher,
  • Rolf Jenni,
  • Firat Duru,
  • Walter J Paulus,
  • Pedro Brugada

DOI
https://doi.org/10.1371/journal.pone.0079152
Journal volume & issue
Vol. 8, no. 11
p. e79152

Abstract

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BackgroundAlthough the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.Methods and resultsECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, pConclusionsA novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI.