Frontiers in Pharmacology (May 2022)

Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

  • Huaqiang Tao,
  • Yunxia Tao,
  • Chen Yang,
  • Wenming Li,
  • Wei Zhang,
  • Xueyan Li,
  • Ye Gu,
  • Yujing Hong,
  • Huilin Yang,
  • Yu Liu,
  • Xing Yang,
  • Dechun Geng,
  • Dechun Geng

DOI
https://doi.org/10.3389/fphar.2022.875611
Journal volume & issue
Vol. 13

Abstract

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Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus resulting in decreased osteoclast-related markers and bone loss.

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